ADVANCES & ANALOGIES

ADVANCES AND BREAKTHROUGHS THAT ARE LIKELY TO RESULT, IF “MALT-TARGETING PEPTIDES” CAN CREATE

THE WORLD’S FIRST “PRECISION-GUIDED VACCINES”

AND, ANALOGIES WE USE, TO HELP EXPLAIN WHAT WE ARE DOING.

We use two analogies, to help people develop a quicker and better mental grasp of what we’re doing, and why.

The first analogy is this: it usually takes only a few locomotive engines (such as, about 5), to pull a long freight train, with up to about 200 freight cars, fully loaded with freight . . . across normal, non-mountainous terrain.

In similar ways, it will take only a small number of “targeted transport peptides” to make mucosal vaccine particles appear to be dangerous and important pathogens, which need to be pulled in and processed, by immune cells which can do exactly that, as quickly as possible. So, this approach can create a “transport platform, or system” which can be used to deliver ANY selected antigen/epitope sequence, from ANY pathogen that any vaccine company wants to study, in ANY type of animal. And, mucosal vaccine particles can be created which can carry, for example, only about 15 to 30 “targeted transport peptides”, while carrying hundreds of copies of any selected antigen sequence.

And, to continue the train analogy, any company that wants to ship any type of freight, via train, can choose and use any type of freight car that is well-suited for that type of freight. And, the company that wants to ship its particular type of freight can choose from among flatbed cars, boxcars, tanker cars, coal cars, “hopper cars” (for grains), container cars (for trucking containers), and half a dozen other “even more specialized” types of freight-carrying cars.

In similar ways, any vaccine company can select and use any type of “core particle” it wants to use, from among multiple types of candidate particles (including, for example, phage viruses, disarmed adeno- or other viruses, virus-like particles, killed bacterial cells, etc.). And, any vaccine company can select and use any of numerous chemical, enzymatic, Spy-Tag/Catcher, or other attachment methods, to attach controllable numbers of “targeted transport peptides” to the surfaces of its vaccine particles. All of those options are summarized and reviewed in the “Patent Background” file than can be downloaded, free of charge, via one of the PDF buttons at the bottom of the home page of this website.

Another analogy we offer, to try to help people develop a better mental grasp of what we’re doing (and why), is this: injecting a vaccine into a muscle is like dropping hundreds and hundreds of bombs, out of airplanes flying six miles high, in the hope that SOME of those bombs will hit the actual target(s).

By the time the Vietnam War ended, America’s military and political leaders realized that no enemy country will ever be turned into an ally, by dropping more and more bombs on its people, and on the things they need to make a living, and raise their children. So, experts in electronics, computers, physics, telecommunications, and other areas spent roughly thirty years, figuring out how to create and use “precision-guided munitions”, which eventually led to video-controlled rockets and then drones which could hit a single targeted building, and then, a single moving vehicle, and now, a single targeted person.

And, as the war in Ukraine has proven, those advances have changed the very nature of modern warfare. Why should, and why would, any country allow its young, trained, capable, and highly expensive and costly soldiers, to be simply killed, by remote-controlled devices, when it could fight back, using its own remote controlled devices? For anyone who has not been keeping up with the information being generated on the Ukranian battlefields, two facts are offered, to help them better understand how “modern and future warfare” has been changed, by “remote-controlled munitions”. Fact 1: the average, typical, measurable life expectancy, of a Russian soldier who walks onto an active battleground, in Ukraine, is now estimated to be about 30 seconds. In other words, within about 30 seconds, any young soldier that Russia has paid dearly, to train, and feed, and get ready, will be killed – very, very quickly, if the Russian army is stupid enough to send him simply marching across some open field – by some drone (or swarm of drones) that Ukrainians have learned how to use, as true masters of that particular type of contest. Fact 2: when US soldiers go up against Ukrainian soldiers, in simulated high-tech battlefield conditions . . . the Ukrainians win. Every time. It isn't even a fair contest. The Ukrainians have become so damn good, at using drones and other remote weapons remotely, that they are now the best in the world. And, every country in Europe knows it. They no longer ask US specialists to help train their troops; instead, they ask Ukrainian troops – who have actually figured out, and know, how to use “precision-guided munitions” – to train their troops, and show them how to get ready for the next major war. As quoted by a high-level defense expert for one of the major European countries: “We don't think the Americans have anything they can teach us, that is worthwhile, any more. Not with these kinds of weapons.”

FOUR POTENTIALLY HUGE ADVANCES AND ADVANTAGES, FROM “PRECISION-GUIDED VACCINES”

We have not just one but four powerful reasons – based solidly on science, and on what scientists know about how the immune cells that are involved do their work – for not just hoping, but anticipating and believing, that “precision-guided vaccines” will, within the next 10 years, disrupt, change, and modernize vaccine technology, vaccine usage, vaccine efficacy, and disease prevention, as profoundly as “precision-guided munitions” have disrupted and changed modern and future warfare.

Stated as predictions – which we fully anticipate will be used to measure, and tell the world about, whether we succeeded, or failed – we believe “MALT-targeting precision-guided vaccines” will, within the next 10 years, be able to accomplish each of four major objectives, which are listed below in their likely order of importance:

1. They will be able to trigger and drive the formation of, not just the Y-shaped internal IgG antibodies that can be triggered by injected vaccines, but also, SECRETED MUCOSAL IgA ANTIBODY DIMERS. As described elsewhere, THERE ARE MORE THAN TWICE AS MANY SECRETED IgA ANTIBODY DIMERS, IN JUSTG THE FEW POUNDS OF SALIVA, NASAL MUCOUS, LUNG FLUIDS, AND DIGESTIVE JUICES, THAN ALL OF THE INTERNAL Y-SHAYTED IgG ANTIBODIES IN THE ENTIRE REMAINING BULK AND WEIGHT OF AN ADULT HUMAN; AND, THAT IS A TRULY POWERFUL INDICATOR OF HOW IMPORTANT THOSE SECRETED ANTIBODY DIMERS ARE. For complex reasons, secreted mucosal antibody dimers can do more actual good than internal Y-shaped antibodies, at blocking the mucosal surface "beachheads" where most pathogens establish an initial infection, and begin reproducing, so that their progeny can begin moving and penetrating deeper into the body of a victim. However, until now, immunologists simply have not been able to find any consistent, reliable ways to create vaccines that will effectively trigger the formation of the types of secreted mucosal antibody dimers that can block the earliest stages of infections by mucosal pathogens.

2. They are likely to become the fastest-acting vaccines that have ever been created, for two reasons: (i) our tests to date show that phages with MALT-targeting peptides can cause “immature dendritic cells” to fully convert into “mobile antigen-presenting cells” within only 90 minutes after infusion of the phages, into the nostrils, begins; and, (ii) when those newly converted dendritic cells leave the docking site behind an M cell, and begin searching for a germinal center inside a lymph node, they will already be inside a lymph node. Now, why is “fastest” such a potentially important and valuable trait? Because, during a major epidemic (and even more, during a raging pandemic), or when such an event appears to be beginning to gather steam, faster vaccines are likely to be able to provide huge and crucial advantages, by minimizing the number of people who will become infected, and by minimizing the huge and horrible costs (including risks to caregivers) of caring for those who have become infected.

3. If "MALT-targeting precision-guided vaccines" can be made to work in the ways we believe they can, they will be able to completely eliminate any need for the types of noxious, irritating, inflammatory “adjuvant” additives that must be added to injected vaccines. As described elsewhere, adjuvants do their work by irritating the muscle cells, at the site of an injection, so severely, that those muscle cells will rapidly begin sending out distress signals, in the form of cytokine messenger molecules, which will recruit any nearby immune cells to hustle to the site of the injection, as quickly as possible, so that they can encounter and begin processing the vaccine particles before those vaccine particles are degraded, diffused, or taken in by the cells they contact. Under the current technology, that nasty and painful mechanism is necessary, to make injected vaccines more potent, more effective, and better able to protect larger numbers and higher percentages of the animals and humans that are inoculated by those vaccines.

That third major advantage merits an additional comment. In any other setting, if someone else could find some way to eliminate any need for the types of noxious and inflammatory adjuvants that must be added to injected vaccines, to make them more effective, that would be hailed by experts as a major, major advance, advantage, benefit, and blessing; and, such vaccines likely would be given a new category label, such as “Post-Adjuvant Vaccines”, to proclaim the marvelous and wonderful beginning of a new era, and a new generation, of vaccines.

Therefore, it says something important, about how we regard the even larger and even more important first two listed potential advantages of “Precision-Guided Vaccines.” In our frame of reference, we believe the possibility of eliminating irritating and inflammatory adjuvants, only rises to a level of getting rid of reasonably minor and tolerable levels of irritation. So, that advantage – which would have been a huge, massive, create-a-new-era accomplishment, for anyone else – ranks only third, in our assessment of the improvements and advances that we hope for, and anticipate, from our new types of vaccines.

4. And, finally, as the fourth major advantage, “precision-guided vaccines” will be able to completely eliminate needles, and nearly all other hazardous medical wastes that modern vaccines create. Instead of syringes, needles, and the other “detritus” that injected vaccines create, our vaccines can be embedded in a set of three or four lozenges, to be taken at least 6 hours apart (for a sustained-release dosage), with nothing but a small plastic wrapper, to hold the lozenges. And, they also can greatly reduce any need for refrigeration, or other special handling (which, among other advantages, will make them MUCH better suited for remote and/or tropical areas).